The first source that I found is "Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity". The purpose of this article is to report the findings from an experiment done by a group of scientists. In the experiment they were attempting to develop a more accurate method of using CRISPR Cas9. It has problems and can lead to many mutations when editing a genome and they were attempting to make it more accurate.
The article itself is published in Cell Press which is a leading publisher of biomedical research. Within the article itself it cites dozens of other papers about gene modifications and other genome related research. The authors of the report are F. Ann Ran, Patrick D. Hsu, et al. The group of authors are credible and qualified as they are all related to Harvard or Massachusetts Institute of Technology. Their target audience is other members of the biomedical engineering community who are working on gene engineering or work with CRISPR Cas 9. I found this article through searching "CRISPR/CAS9" in google scholar.
https://csrspreadscience.files.wordpress.com/2015/05/18i2cwilgs7n4jpg.jpg |
URL: http://www.sciencedirect.com/science/article/pii/S0092867414006047
The second source that I found is "Development and Applications of CRISPR-Cas9 for Genome Engineering". I found this article on google scholar when I typed in "CRISPR/CAS9". The purpose of the article is to inform the reader about CRISPR Cas9. It informs them about how it works and also gives a little history about DNA modification. Within the article it references research done by the authors and research done by other researchers. The authors of the piece are Patrick D. Hsu, Eric S. Lander, and Feng Zhang. The intended audience of the article is the biomedical engineering and biology communities who work with genetic engineering. The article was published by Cell Press.
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